The aim of this study was to improve the Dealer Boots treatment of Candida albicans biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic copyright.Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity.Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques.
The results for nystatin solid dispersions showed White Rice Flour that the enhancement of antifungal activity may be related to the high proportions of maltodextrins.Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension.The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.